[HTML][HTML] Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy

Q Meng, Y Li, T Ji, Y Chao, J Li, Y Fu, S Wang… - Journal of Advanced …, 2021 - Elsevier
estrogen can inhibit cardiomyocyte apoptosis and reduce … Until midlife, the cardiovascular
disease incidence in men is … the post-menopausal stage by up-regulating autophagy. …

17β-Estradiol Nanoparticles Increase Endothelial Nitric Oxide Synthase Expression Through Akt Pathway in Rats with Myocardial Infarction

Z Zuo, L Wang, X Liu, R Meng, S Wang… - Journal of …, 2024 - ingentaconnect.com
estrogen in the body. When women cannot secrete estrogens, the risk of cardiovascular
disease will increase … results with 17 -estradiol NPs, up-regulating mRNA expression of Akt and …

Estradiol inhibits human brain vascular pericyte migration activity: a functional and transcriptomic analysis

L Kurmann, M Okoniewski, RK Dubey - Cells, 2021 - mdpi.com
vascular remodeling associated with coronary artery disease … with endothelial cells,
we assessed whether estradiol improves … be triggered by estradiol, we analyzed estradiol-induced …

Estradiol signaling at the heart of folliculogenesis: its potential deregulation in human ovarian pathologies

S Chauvin, J Cohen-Tannoudji, CJ Guigon - International journal of …, 2022 - mdpi.com
… proliferation and motility, while they are more effective in up-regulating apoptotic genes [164].
These data open a promising perspective and need to be investigated on GCT growth. …

Liuwei Dihuang prevents postmenopausal atherosclerosis and endothelial cell apoptosis via inhibiting DNMT1-medicated ERα methylation

Q Chen, Y Zhang, Q Meng, S Wang, X Yu, D Cai… - Journal of …, 2020 - Elsevier
… It has been reported that LWDH could improve estrogen receptor α (ERα) expression to
prevent atherosclerosis (AS), while the mechanism of LWDH on regulating ERα expression was …

Qixian granule inhibits ferroptosis in vascular endothelial cells by modulating TRPML1 in the lysosome to prevent postmenopausal atherosclerosis

M Zhang, C Mao, Y Dai, X Xu, X Wang - Journal of Ethnopharmacology, 2024 - Elsevier
… ferroptosis in vascular endothelial cells through up-regulating GPER/… attributed to the
cardiovascular protective effect of estrogen, although its … Coronary heart disease in women …

Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells through PI3K/AKT pathway

X Li, S Sun, D Chen, T Yuan, Y Chen, D Wang… - European Journal of …, 2020 - Elsevier
… of apoptosis in EndMT is essentially unknown at present, prior studies have documented that
apoptosis … for us to further study whether puerarin exerts an anti-apoptotic effect in EndMT. …

The effect of melatonin on sheep endometrial epithelial cell apoptosis through the receptor and non-receptor pathways

H Duan, S Yang, J Zeng, J Lv, L Zhang, X Du… - General and …, 2023 - Elsevier
Estrogen reportedly inhibits the apoptosis of uterine stromal cells by up-regulating the … of
melatonin in the inhibition of apoptosis, we added the estrogen receptor antagonist ICI182780, …

Research progress on the mechanism of aging of vascular endothelial cells and the intervention of traditional Chinese medicine: A review

J Wen, C Liu, C Deng - Medicine, 2022 - journals.lww.com
… Ⅱ promotes endothelial cell senescence by up-regulating the … of cerebral infarction and
coronary heart disease. Recent … stress through estrogen receptors, delay cell senescence, and …

The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology

F Xu, J Ma, X Wang, X Wang, W Fang, J Sun, Z Li, J Liu - Biomolecules, 2023 - mdpi.com
… was higher in coronary artery endothelial cells isolated from … Estrogen prevented the
apoptosis of VSMCs, thereby inhibiting the proliferation of human cerebral VSMCs by up-regulating